Association between cord blood IgE and genetic polymorphisms of interleukin-4, the β-subunit of the high-affinity receptor for IgE, lymphotoxin-α, and tumor Necrosis factor-α

Authors: Wen, Hui-Ju1; Lin, Ying-Chu; Lee, Yung-Ling1; Guo, Yueliang Leon2

Source: Pediatric Allergy and Immunology, Volume 17, Number 7, November 2006 , pp. 489-494(6)

Publisher: Blackwell Publishing

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Abstract:

Wen HJ, Lin YC, Lee YL, Guo YL. Association between cord blood IgE and genetic polymorphisms of interleukin-4, the β-subunit of the high-affinity receptor for IgE, lymphotoxin-α, and tumor Necrosis factor-α.

Pediatr Allergy Immunol 2006: 17: 489-494. © 2006 The Authors Journal compilation © 2006 Blackwell Munksgaard

High cord blood immunoglobulin E (cbIgE) is known to be associated with increased risks of atopic diseases in childhood. The relationship between genetic polymorphisms and high cbIgE has not been well documented. A cross-sectional study was conducted to assess the association between cbIgE and genetic polymorphisms of interleukin (IL)-4 -590C/T, the β-subunit of the high-affinity receptor for IgE (FcɛRI-β) E237G, lymphotoxin (LT)-αNcoI alleles, and tumor necrosis factor (TNF)-α -308G/A. A total of 320 mother-neonate pairs were recruited from four maternity hospitals from different locations of Taiwan. Cord blood was obtained and assayed for cbIgE. Polymerase chain reaction followed by restriction fragment length polymorphism was used to assess the genotypes. Three hundred pairs of mothers and neonates were included in the final analysis. Infants with IL-4 -590 C allele were found to have higher risk of elevated cbIgE (≥0.35 IU/ml, 24.3%) (p = 0.004). After adjusting for gender, birth order, maternal age, and history of allergic disease in maternal and paternal families, odds ratios for CC and CT genotypes were 4.41 and 3.16 (95% confidence interval 0.78-22.67, and 1.66-6.13), respectively, using TT genotype as reference. The genotypes of FcɛRI-β, LT-α, and TNF-α were not associated with cbIgE before or after the adjustment. Our finding suggested a significant association of cbIgE with genetic polymorphism of IL-4 -590C/T, but not with the genotypes of FcɛRI-β, LT-α, and TNF-α.

Keywords: allergic disease; genetic polymorphism; cord blood IgE; interleukin-4; the β-subunit of the high-affinity receptor for IgE; lymphotoxin-α; tumor necrosis factor-α

Document Type: Research article

DOI: 10.1111/j.1399-3038.2006.00461.x

Affiliations: 1: Department of Environmental and Occupational Health, National Cheng Kung University Medical College, Tainan, Taiwan 2: Department of Environmental and Occupational Medicine, National Taiwan University Medical College and NTU Hospital, Taipei, Taiwan

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