@article {Bakirtas:September 2006:0905-6157:428,
	author = "Bakirtas, Arzu",
	author = "Turktas, Ipek",
	title = "Airway hyper-responsiveness to adenosine 5-monophosphate in preschool-age children with asthma",
	journal = "Pediatric Allergy and Immunology",
	volume = "17",
	year = "September 2006",
	abstract = "Bakirtas A and Turktas I. Airway hyper-responsiveness to adenosine 5&#8242;-monophosphate in preschool-age children with asthma.<P></P>Pediatr Allergy Immunol 2006: 17: 428-434. &#169; 2006 The Authors Journal compilation &#169; 2006 Blackwell Munksgaard <P></P>Airway hyper-responsiveness (AHR) to adenosine 5&#8242;-monophosphate (AMP) is closely associated with airway inflammation; however, not all asthmatic patients are responsive to it. This study was planned to investigate the predictive factors of AHR to AMP in asthmatic children aged between 3 and 6&#8201;yr.<P></P>We performed a retrospective analysis of data from 63 asthmatic preschool-age children who were challenged by AMP in our department. All children were characterized by skin-prick tests, serum immunoglobulin E (IgE) levels, peripheral blood eosinophil percentage and bronchial challenge with methacholine (MCH) and AMP. Potential determinants for AHR to AMP were assessed within the group.<P></P>AHR to AMP was found in 46&#37; of preschool-age children with asthma, while that of MCH was 93.7&#37;. All children responsive to AMP were also responsive to MCH. The geometric mean provocative concentration of MCH and AMP causing a 15&#37; fall in transcutaneous oxygen tension (PC<SUB>15</SUB>PtcO<SUB>2</SUB>MCH and AMP) were 0.55&#8201;mg/ml (0.004-9.19) and 10.53&#8201;mg/ml (0.59-342.89), respectively. AMP-responsive children did not differ from non-responsive ones with respect to demographic factors, geometric mean PC<SUB>15</SUB>PtcO<SUB>2</SUB>MCH and atopic status. The median serum IgE level was significantly higher in AMP-responsive group than the non-responsive ones (p&#8201;=&#8201;0.011). The peripheral blood eosinophilia was more frequent among responsive children (p&#8201;=&#8201;0.019), and it was found as the only predictive factor for AMP responsiveness in preschool-age children with asthma in logistic regression model (odds ratio: 5.14; 95&#37; CI: 1.23-21.47; p&#8201;=&#8201;0.025). AMP responsiveness may be predicted by peripheral blood eosinophilia but not with atopy markers in young children with asthma.",
	pages = "428-434(7)",
	url = "http://www.ingentaconnect.com/content/mksg/pai/2006/00000017/00000006/art00007"
	doi = "doi:10.1111/j.1399-3038.2006.00411.x"
}