Airway hyper-responsiveness to adenosine 5′-monophosphate in preschool-age children with asthma
Authors: Bakirtas, Arzu; Turktas, Ipek
Source: Pediatric Allergy and Immunology, Volume 17, Number 6, September 2006 , pp. 428-434(7)
Publisher: Blackwell Publishing
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Abstract:
Bakirtas A and Turktas I. Airway hyper-responsiveness to adenosine 5′-monophosphate in preschool-age children with asthma.Pediatr Allergy Immunol 2006: 17: 428-434. © 2006 The Authors Journal compilation © 2006 Blackwell Munksgaard Airway hyper-responsiveness (AHR) to adenosine 5′-monophosphate (AMP) is closely associated with airway inflammation; however, not all asthmatic patients are responsive to it. This study was planned to investigate the predictive factors of AHR to AMP in asthmatic children aged between 3 and 6 yr.We performed a retrospective analysis of data from 63 asthmatic preschool-age children who were challenged by AMP in our department. All children were characterized by skin-prick tests, serum immunoglobulin E (IgE) levels, peripheral blood eosinophil percentage and bronchial challenge with methacholine (MCH) and AMP. Potential determinants for AHR to AMP were assessed within the group.AHR to AMP was found in 46% of preschool-age children with asthma, while that of MCH was 93.7%. All children responsive to AMP were also responsive to MCH. The geometric mean provocative concentration of MCH and AMP causing a 15% fall in transcutaneous oxygen tension (PC15PtcO2MCH and AMP) were 0.55 mg/ml (0.004-9.19) and 10.53 mg/ml (0.59-342.89), respectively. AMP-responsive children did not differ from non-responsive ones with respect to demographic factors, geometric mean PC15PtcO2MCH and atopic status. The median serum IgE level was significantly higher in AMP-responsive group than the non-responsive ones (p = 0.011). The peripheral blood eosinophilia was more frequent among responsive children (p = 0.019), and it was found as the only predictive factor for AMP responsiveness in preschool-age children with asthma in logistic regression model (odds ratio: 5.14; 95% CI: 1.23-21.47; p = 0.025). AMP responsiveness may be predicted by peripheral blood eosinophilia but not with atopy markers in young children with asthma.Keywords: adenosine 5′-monophosphate; airway hyper-responsiveness; asthma; children
Document Type: Research article
DOI: 10.1111/j.1399-3038.2006.00411.x
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