Authors: Nagao, Toru; Warnakulasuriya, Saman¹; Ikeda, Noriaki²; Fukano, Hideo³; Yamamoto, Shigeo⁴; Yano, Masatoshi⁵; Miyazaki, Hideo⁵; Ito, Yoshinori⁶

Source: Journal of Oral Pathology & Medicine, Volume 30, Number 5, May 2001 , pp. 264-267(4)

Publisher: Wiley-Blackwell

Abstract:

:

The aim of this study was to elucidate any association between oral lichen planus (OLP) and serum antioxidant micronutrients by a population-based case-control study. A total of 9536 subjects were examined, and 62 (58 reticular, 4 atrophic and erosive) diagnosed with OLP at referral facilities were compared with four controls per case (n=248) selected among disease-free subjects matched for age and sex. Serum levels of micronutrients (retinol, α-tocopherol, zeaxanthin/lutein and cryptoxanthin, lycopene, α-carotene and β-carotene) were estimated by the high performence liquid chromatography (HPLC) method. Among cases, mean serum retinol level (2.820±0.849 μmol/l) was significantly higher compared with that of controls (2.562±0.735 μmol/l) (P<0.05). No significant differences were noted in carotenoid levels examined in this study, except for a lower level of lycopene found in atrophic/erosive OLP cases. The results of this study suggest that low serum retinol or carotenoid levels are not risk factors for occurrence of lichen planus, and any specific benefits of antioxidant micronutrients cannot be claimed for this inflammatory disorder.

Keywords: antioxidants; β-carotene; carotenoids; epidemiology; lycopene; oral lichen planus (OLP); micronutrients; mouth mucosa; retinoid

Document Type: Research article

DOI: http://dx.doi.org/10.1034/j.1600-0714.2001.300502.x

Affiliations: 1: Department of Oral Medicine and Pathology, Guy's, King's & St Thomas' Dental Institute, King's College, London, UK 2: Bureau of International Cooperation, International Medical Center of Japan, Tokyo, Japan 3: Department of Oral and Maxillofacial Surgery, Osaka Prefectural Hospital, Osaka, Japan 4: Second Department of Oral and Maxillofacial Surgery, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan 5: Department of Preventive Dentistry, Niigata University, School of Dentistry, Niigata, Japan and 6: Department of Public Health, Fujita Health University School of Health Sciences, Aichi, Japan

Publication date: 2001-05-01

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