Adapter and enzymatic functions of proteases in T-cell activation

Authors: Hailfinger, Stephan; Rebeaud, Fabien; Thome, Margot

Source: Immunological Reviews, Volume 232, Number 1, November 2009 , pp. 334-347(14)

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Abstract:

Summary:

Proteases control many vital aspects of humoral and cellular immune responses, including the maturation of cytokines and the killing of target cells. Recently, it has become evident that triggering of the T-cell receptor controls T-cell proliferation through proteases such as mucosa-associated lymphoid tissue 1 (MALT1) and Caspase-8 that act both as adapters and enzymes. Here, we discuss the role of these and other proteases that are relevant to the control of the T-cell response and represent interesting targets of therapeutic immunomodulation.

Keywords: lymphoma; antigen receptor; NF-κB; adhesion; paracaspase; Caspase-8

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1600-065X.2009.00830.x

Affiliations: 1: Department of Biochemistry, University of Lausanne, Epalinges, Switzerland.

Publication date: 2009-11-01