Modeling immune behavior for experimentalists

Author: Cohen, Irun R.

Source: Immunological Reviews, Volume 216, Number 1, April 2007 , pp. 232-236(5)

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Abstract:

Summary:

This article outlines the requirements for useful models of biologic systems. Such models should fulfill three conditions: (i) suit the bottom-up data of the living system, not merely adhere to top-down logic; (ii) abet experimentation by stimulating new ideas for novel experiments; and (iii) engage the mind of the experimentalist with understandable, visual representations. Seven characteristics of a useful model are discussed.

Keywords: theoretical immunology; immune system modeling; computer modeling

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1600-065X.2006.00494.x

Publication date: 2007-04-01