Response of aged mice to primary virus infections

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In this Subject: <a title="Anatomy & Physiology" href="/content/subcat?j_subject=157&j_availability=">Anatomy & Physiology ,&nbsp; <a title="Allergy & Immunology" href="/content/subcat?j_subject=197&j_availability=">Allergy & Immunology
By this author: Murasko, Donna M. ;&nbsp; Jiang, Jiu

Authors: Murasko, Donna M.; Jiang, Jiu

Source: Immunological Reviews, Volume 205, Number 1, June 2005 , pp. 285-296(12)

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Abstract:

Summary:

Aging is associated with an increased morbidity to virus infections as well as a delay in clearance of symptoms after infection. Studies of sublethal virus infections of aged mice closely mirror the human situation: there is a delay in clearance of virus. The delay in virus clearance is accompanied by a delay and a decrease in T-cell response, particularly of CD8⁺ T cells. Intrinsic alterations of T cells of aged mice contribute to this decrease in virus-specific T-cell response; however, evidence suggests that environmental or innate components of the aged host also influence this age-associated decline in clearance of virus. While the changes in the adaptive immune response have been carefully described, the early events in the generation of the T-cell response after virus infection have received limited attention. Importantly, age-associated changes in the innate response to virus infection, particularly production of and response to interferon (IFN)- agr

, cytotoxicity and IFN- gamma

production by natural killer cells, interleukin-12 induction, and depletion of non-specific T cells early during virus infection need further evaluation.