Cytomegalovirus: its potential role in the development of cutaneous T-cell lymphoma

Authors: Ballanger, F.¹; Bressollette, C.²; Volteau, C.³; Planche, L.³; Dreno, B.¹

Source: Experimental Dermatology, Volume 18, Number 6, June 2009 , pp. 574-576(3)

Buy & download fulltext article:

Price: $48.00 plus tax (Refund Policy)

Abstract:

Please cite this paper as: Cytomegalovirus: its potential role in the development of cutaneous T-cell lymphoma. Experimental Dermatology 2009; 18: 574-576. Abstract:

To investigate the potential role of CMV in cutaneous T-cell lymphoma (CTCL), we studied cytomegalovirus (CMV) seroprevalence in parapsoriasis (PP), mycosis fungoides (MF) and Sézary syndrome (SS) compared with healthy control patients. In cases where CMV seropositivity was observed, CMV PCR analyses were performed on skin biopsies. CMV seroprevalence was 37.1% in the control group, 50.68% in the PP + MF + SS group (P = 0.08), 56.2% in the MF + SS group (P = 0.07), 40% in the PP group (P = 0.9), 66.67% in the MF group (P = 0.009), 42.86% in the SS group (P = 0.9). CMV PCR in initial skin biopsies were all negative. However, PCR CMV was positive in two SS skin biopsies realized at an advanced stage. Our results show that latent CMV infection may play a role in the susceptibility of MF in predisposed subjects by inducing T-cell proliferation and resistance to apoptosis. Concerning SS, an immunosuppressive state may be responsible for CMV reactivation that in turn may interfere with evolution of the disease.

Keywords: cutaneous T-cell lymphoma; cytomegalovirus; mycosis fungoides; Sézary syndrome

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1600-0625.2008.00817.x

Affiliations: 1: Department of Skin Cancer, CHU Hôtel Dieu, Nantes Cedex, France; 2: Department of Virology, CHU Hôtel Dieu, Nantes Cedex, France; 3: Clinical Research Department, Methodological Unit, CHU Hôtel Dieu, Nantes Cedex, France

Publication date: 2009-06-01