Histological comparison of alendronate, calcium hydroxide and formocresol in amputated rat molar

Authors: Burcak Cengiz, S.¹; Batirbaygil, Yildiz¹; Onur, Mehmet Ali²; Atilla, Pergin³; Asan, Esin³; Altay, Nil¹; Cehreli, Zafer C.¹

Source: Dental Traumatology, Volume 21, Number 5, October 2005 , pp. 281-288(8)

Publisher: Wiley-Blackwell

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Abstract:

Cengiz SB, Batirbaygil Y, Onur MA, Atilla P, Asan E, Altay N, Cehreli ZC. Histological comparison of alendronate, calcium hydroxide and formocresol in amputated rat molar. Dent Traumatol 2005; 21: 281–288. © Blackwell Munksgaard, 2005. Abstract –

The purpose of this study was to evaluate the potential of alendronate sodium (ALN), a biphosohonate to stimulate hard tissue formation in pulpotomized (amputated) rat molars. Two commonly used pulpotomy materials, calcium hydroxide (CH) and formocresol (FC) were utilized for comparisons. Histological evaluations were performed by observers blinded to treatment allocation on days 7, 15, 30 and 60, followed by statistical analysis of selected histological criteria. In all evaluation periods, hard tissue deposition was evident along the radicular dentin in ALN and CH groups. In days 30 and 60, the latter two groups showed no differences in inflammatory cell response and hard tissue deposition scores (P > 0.05). ALN appears to be capable of maintaining pulpal vitality, while promoting hard tissue formation, similar to CH.

Keywords: biphoshponates; alendronate; calcium hydroxide; formocresol; pulpotomy; pulp capping dental; adverse effects

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1600-9657.2005.00325.x

Affiliations: 1: Department of Pediatric Dentistry, Faculty of Dentistry 2: Department of Biology, Faculty of Science 3: Department of Histology and Embryology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

Publication date: 2005-10-01