Definition of the features of acquired elastotic hemangioma reporting the clinical and histopathological characteristics of 14 patients
Methods: Fourteen cases of acquired elastotic hemangioma were retrieved from the files of the Dermatopathology Unit at Wake Forest University School of Medicine.
Results: Acquired elastotic hemangioma affects sun-damaged skin of upper extremities and neck. Clinically, lesions present as slowly growing, painless, solitary, erythematous plaques. Histopathologically, they are characterized by a horizontal proliferation of capillary blood vessels in the upper reticular dermis in a background of solar elastosis. The vessels have plump endothelial cells that protrude into the vascular lumens in a ‘hobnail’ pattern. Of the 10 cases assessed by immunohistochemistry, 100% (10) expressed CD31 and CD34, 90% (9) expressed D2-40 and 10% (1) expressed SMA.
Conclusion: Acquired elastotic hemangioma is a distinctive variant of hemangioma which should be differentiated from other cutaneous vascular tumors with a hobnail endothelial pattern, including angiosarcoma. The expression of D2-40 in most cases suggests a lymphatic origin of this acquired vascular proliferation.
Martorell-Calatayud A, Balmer N, Sanmartín O, Díaz-Recuero JL, Sangueza OP. Definition of the features of acquired elastotic hemangioma reporting the clinical and histopathological characteristics of 14 patients.
Document Type: Research Article
Affiliations: 1: Pathology Department, Wake Forest University, Winston Salem, North Carolina, USA 2: Dermatology Department, Fundación Instituto Valenciano de Oncología, Valencia, Spain 3: Pathology Department, Fundación Jiménez Díaz, Madrid, Spain
Publication date: 2010-04-01