@article {Mason:April 2006:0303-6987:309, author = "Mason, Stephen E.", author = "Smoller, Bruce R.", author = "Wilkerson, Anne E.", title = "Colchicine intoxication diagnosed in a skin biopsy: a case report", journal = "Journal of Cutaneous Pathology", volume = "33", year = "April 2006", abstract = ":
Colchicine toxicity is a rare, but well-described clinical entity. The histopathologic findings in various organ systems have been delineated in colchicine intoxication; however, skin findings have only been described in rare cases. We present a case of colchicine toxicity diagnosed on skin biopsy in a patient presenting with mental status changes. Her cutaneous manifestation consisted of a diffuse, blanchable, violaceous, morbilliform rash involving the trunk and proximal extremities. The histopathologic findings included metaphase-arrested keratinocytes with underlying basal vacuolization. These features, considered in the setting of multiorgan dysfunction and a known exposure of colchicine, led to the diagnosis. Mason SE, Smoller BR, Wilkerson AE. Colchicine intoxication diagnosed in a skin biopsy: a case report.", pages = "309-311(3)", url = "http://www.ingentaconnect.com/content/mksg/cup/2006/00000033/00000004/art00007" doi = "doi:10.1111/j.0303-6987.2006.00393.x" }