Colchicine intoxication diagnosed in a skin biopsy: a case report
Authors: Mason, Stephen E.1; Smoller, Bruce R.1; Wilkerson, Anne E.2
Source: Journal of Cutaneous Pathology, Volume 33, Number 4, April 2006 , pp. 309-311(3)
Publisher: Wiley-Blackwell
Abstract:
: Colchicine toxicity is a rare, but well-described clinical entity. The histopathologic findings in various organ systems have been delineated in colchicine intoxication; however, skin findings have only been described in rare cases. We present a case of colchicine toxicity diagnosed on skin biopsy in a patient presenting with mental status changes. Her cutaneous manifestation consisted of a diffuse, blanchable, violaceous, morbilliform rash involving the trunk and proximal extremities. The histopathologic findings included metaphase-arrested keratinocytes with underlying basal vacuolization. These features, considered in the setting of multiorgan dysfunction and a known exposure of colchicine, led to the diagnosis. Mason SE, Smoller BR, Wilkerson AE. Colchicine intoxication diagnosed in a skin biopsy: a case report.Document Type: Research article
DOI: http://dx.doi.org/10.1111/j.0303-6987.2006.00393.x
Affiliations: 1: Department of Pathology, Vanderbilt University, Nashville, TN, and 2: Department of Pathology, University of Arkansas Medical Sciences, Little Rock, AR
Publication date: 2006-04-01
- In this: publication
- By this: publisher
- In this Subject: Dermatology
- By this author: Mason, Stephen E. ; Smoller, Bruce R. ; Wilkerson, Anne E.

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