Basal cell carcinoma with matrical differentiation: a case study with analysis of β-catenin

Authors: Haskell, Henry D.; Haynes, Harley A.; McKee, Phillip H.; Redston, Mark; Granter, Scott R.; Lazar, Alexander J. F.

Source: Journal of Cutaneous Pathology, Volume 32, Number 3, March 2005 , pp. 245-250(6)

Publisher: Wiley-Blackwell

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Abstract:

Matrical differentiation in basal cell carcinoma (BCC) is rare. Only nine cases have been described that showed typical diagnostic features of BCC, in addition to shadow cells indicating hair-matrix differentiation. ^1–5 These cases often present a diagnostic challenge due to confusion with pilomatrixoma or pilomatrix carcinoma. We present a case of BCC with matrical differentiation in a 78-year-old man. Immunohistochemical and molecular methods are used to differentiate this lesion from benign or malignant forms of pilomatrixoma. Haskell HD, Haynes HA, McKee PH, Redston M, Granter SR, Lazar AJF. Basal cell carcinoma with matrical differentiation: a case study with analysis of β-catenin.

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.0303-6987.2005.00301.x

Affiliations: 1: Department of Pathology, Division of Dermatopathology (H.D.H, P.H.M., M.R., S.R.G., A.J.F.L) and Department of Dermatology (H.A.H), Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA

Publication date: 2005-03-01