IngentaConnect Apoptosis in the areas of squamous differentiation of irritated s...

Authors: Pesce C.; Scalora S.

Source: Journal of Cutaneous Pathology, Volume 27, Number 3, March 2000 , pp. 121-123(3)

Abstract:

Seborrheic keratosis (SK) consists of a localized proliferation of basaloid keratinocytes, often accompanied by hyperkeratosis and hyperpigmentation. In irritated SK, these features are associated with areas of squamous differentation with larger keratinocytes and squamous cell eddies. This work is concerned with the evaluation of apoptosis, as demonstrated by the TUNEL method, in the different varieties of SK. Apoptosis was highly expressed in the areas of squamous differentiation of irritated SK, but only mildly increased in the other varieties of SK. These data support the hypothesis that apoptosis has a role in the squamous differentiation of irritated SK. In consideration also of previous data showing that irritated SK is associated with downregulation of EGF-R expression and ¹²⁵I-EGF binding, we postulate that the morphologic features of irritated SK could correspond to an involution phase of the disease, characterized by altered cell balance with inadequate cell renewal and increased cell loss.

Language: English

Document Type: Original article

DOI: 10.1034/j.1600-0560.2000.027003121.x

Affiliations: Università di Genova, DISTBIMO, Centro di Anatomia Patologica, Genova, Italy : *

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Apoptosis in the areas of squamous differentiation of irritated seborrheic keratosis