Authors: Andersen, Klaus Ejner; Christensen, Lars Porskjær¹; Vølund, Aage²; Johansen, Jeanne Duus³; Paulsen, Evy

Source: Contact Dermatitis, Volume 60, Number 3, March 2009 , pp. 155-157(3)

Publisher: Wiley-Blackwell

Abstract:

Background: 

Both epoxy resin (diglycidyl ether of bisphenol A) and fragrance mix I are included in the European baseline series of contact allergens. A significant association between positive reactions to epoxy resin and fragrance mix has been reported by others. Objective: 

To investigate and possibly reproduce this association with the use of TRUE^® test data and supplementary tests with fragrance mix ingredients from the Department of Dermatology, Odense University Hospital. Materials and Methods: 

Six thousand one hundred and fifteen consecutive eczema patients tested from 1995 to 2007 were included, and test results from all patients tested with fragrance mix ingredients were analysed. Results: 

One hundred and forty-five (2.4%) were positive to epoxy resin and 282 (4.6%) were positive to fragrance mix I. Nineteen were positive to both giving an odds ratio of 3.3, which is significant (95% CI 2.0-5.4). Analysis of association to individual fragrance mix ingredients showed a significant association to α-amyl cinnamal and isoeugenol. Conclusions: 

The significant association between positive reactions to epoxy resin and fragrance mix I was reproduced. However, the clinical implications are not clarified, and even though the association may be coincidental, the fact that it can be reproduced with a different patch test system and in a different population speaks against a random result. Further studies may help to interpret the association.

Keywords: concomitant reaction; cross-reaction; diglycidyl ether of bisphenol A; epoxy resin; fragrance mix I; patch tests

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1600-0536.2008.01498.x

Affiliations: 1: Institute of Chemical Engineering, Biotechnology and Environmental Technology, University of Southern Denmark, 5230 Odense M 2: Skovholmvej 8, 2920 Charlottenlund, Denmark 3: The National Allergy Research Centre, Ledreborg Alle, 2820 Gentofte

Publication date: 2009-03-01

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