Occupational allergic contact dermatitis caused by isocyanates

Authors: Goossens A.¹; Detienne T.¹; Bruze M.²

Source: Contact Dermatitis, Volume 47, Number 5, November 2002 , pp. 304-308(5)

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Abstract:

Between 1978 and 2001, 22 patients were diagnosed with occupation-related allergic contact dermatitis from isocyanates and/or polyurethanes in our clinic. 13 had a positive reaction to the isocyanates, of whom 10 also reacted to diaminodiphenylmethane (MDA), which is used in the production or processing of isocyanates and polyurethanes; 9 reacted only to MDA. The object of the present study was to identify the trades and industries responsible for the development of contact allergy to these resins. Such patients must be patch tested with the isocyanates contacted at work, and account must be taken of positive reactions to MDA as a marker for isocyanate sensitivity.

Keywords: airborne; allergic contact dermatitis; diaminodiphenylmethane; diphenylmethane diisocyanate; hexamethylene diisocyanate; isocyanates; occupational; polyurethane; resins; toluene diisocyanate

Document Type: Research article

DOI: http://dx.doi.org/10.1034/j.1600-0536.2002.470509.x

Affiliations: 1: Department of Dermatology, University Hospital, Katholieke Universiteit Leuven, Leuven, Belgium, 2: Department of Occupational and Environmental Dermatology, University Hospital Malmö, Malmö, Sweden

Publication date: 2002-11-01