Sensitizing capacity and cross-reaction pattern of the isomers of diglycidyl ether of bisphenol F in the guinea pig

Authors: Pontén A.; Zimerson E.; Sörensen Ö.; Bruze M.

Source: Contact Dermatitis, Volume 47, Number 5, November 2002 , pp. 293-298(6)

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Abstract:

In this study, the sensitizing capacities of the 3 main low-molecular-weight isomers of epoxy resins based on diglycidyl ether of biphenol F (DGEBF) were investigated in a guinea pig maximization test (GPMT). The isomers are p,p prime

-DGEBF, o,p prime

-DGEBF, and o,o prime

-DGEBF. The sensitization capacities were compared to diglycidyl ether of bisphenol A (DGEBA), which is the main constituent in the most common epoxy resin. The cross-reaction pattern between all 4 compounds was also investigated. It was found that all 3 DGEBF isomers were potent sensitizers. It was also found that p,p prime

-DGEBF, o,p prime

-DGEBF, and DGEBA cross-reacted with one another, and that animals induced with o,o prime

-DGEBF reacted significantly only to o,p prime

-DGEBF, but not to the other 2 DGEBF isomers or DGEBA.

Keywords: cross-reaction; DGEBA; DGEBF; diglycidyl ether of bisphenol A; diglycidyl ether of bisphenol F; epoxy resin; GPMT; isomer; sensitizing capacity. © Blackwell Munksgaard; 2002

Document Type: Research article

DOI: http://dx.doi.org/10.1034/j.1600-0536.2002.470507.x

Affiliations: 1: Department of Occupational and Environmental Dermatology, Malmö University Hospital, Malmö, Sweden

Publication date: 2002-11-01