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Allergic contact dermatitis from sodium dihydroxycetyl phosphate, a new cosmetic allergen?

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Sodium dihydroxycetyl phosphate (trade name Dragophos S 2/918501) was identified as a contact allergen in a herbal moisturizing cream causing severe acute contact dermatitis on the hands and face of a 41-year-old woman. Sodium dihydroxycetyl phosphate is a complex mixture of phosphate esters of dihydroxycetyl alcohol, and subsequent analysis and testing revealed hexadecane-1,2-diol as 1 of the allergenic ingredients. Another possible allergen in the compound appears to be hexadecane-1,2-diol, 2-isopropyl ether.
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Keywords: allergic contact dermatitis; cosmetics; cross-sensitivity; emulsifiers; hexadecane-1,2-diol; phosphorus compound; sodium dihydroxycetyl phosphate; surfactants

Document Type: Research Article

Affiliations: 1: Department of Dermatology, Odense University Hospital, DK-5000 Odense C, Denmark 2: National Environmental Research Institute, DK-4000 Roskilde, Denmark

Publication date: 01 September 2001

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