Evaluation of platelet-rich plasma in combination with freeze-dried bone in the rabbit cranium: A pilot study
Authors: Aghaloo Tara L.1; Moy Peter K.2; Freymiller Earl G.1
Source: Clinical Oral Implants Research, Volume 16, Number 2, April 2005 , pp. 250-257(8)
Publisher: Blackwell Publishing
- Free Content
- New Content
- Subscribed Content
- Free Trial Content
Abstract:
: Platelet-rich plasma (PRP) offers a new and potentially useful adjunct to allograft materials in oral and maxillofacial bone and implant reconstructive surgery. This study compares bone healing in four cranial defects in the rabbit grafted with freeze-dried mineralized bone (FMB) alone, FMB+PRP, freeze-dried demineralized bone (FDDB) alone, and FDDB+PRP. Fifteen New Zealand white rabbits were included in this randomized, blind, prospective pilot study. Four equal 8 mm diameter defects were created in each rabbit cranium and immediately grafted with the above materials. Five rabbits were evaluated at 1, 2, and 4 months. Radiographically, FMB+PRP showed a tendency toward increased bone density over FMB alone, but was not statistically significant (P>0.05), and FDDB+PRP showed a tendency toward increased bone density over FDDB alone, but was not statistically significant (P>0.05). Histomorphometrically, FMB+PRP showed a tendency toward increased bone area over FMB alone at 1 and 4 months, but was not statistically significant (P>0.05), and FDDB+PRP showed a tendency toward increased bone area over FDDB alone, at 1 and 2 months, but was not statistically significant (P>0.05). This study failed to show a radiographic or histomorphometric increase in bone formation with the addition of PRP to either FMB or FDDB in non-critical-sized defects in the rabbit cranium. To cite this article:Aghaloo TL, Moy PK, Freymiller EG. Evaluation of platelet-rich plasma in combination with freeze-dried bone in the rabbit cranium. A pilot study. Clin. Oral Impl. Res. doi: 10.1111/j.1600-0501.2004.01075.xKeywords: animal study; bone grafting; cranial defects; freeze-dried demineralized bone; freeze-dried mineralized bone; histomorphometry; platelet-rich plasma
Document Type: Research article
DOI: 10.1111/j.1600-0501.2004.01075.x
Affiliations: 1: Oral and Maxillofacial Surgery, School of Dentistry, UCLA, Los Angeles, CA, USA 2: Oral and Maxillofacial Surgery, School of Dentistry, UCLA, Brentwood, CA, USA
- Free Content
- New Content
- Subscribed Content
- Free Trial Content
Click here for Page Help