Bipolar affective disorder in a male with a deletion of Y chromosome – a case report

Authors: Olajossy, Marcin¹; Olajossy-Hilkesberger, Luiza¹; Tkaczuk-W lstrok ach, Joanna²

Source: Bipolar Disorders, Volume 7, Number 3, June 2005 , pp. 298-301(4)

Publisher: Wiley-Blackwell

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Abstract:

Olajossy M, Olajossy-Hilkesberger L, Tkaczuk-W lstrok

ach J. Bipolar affective disorder in a male with a deletion of Y chromosome – a case report.

Bipolar Disord 2005: 7: 298–301. © Blackwell Munksgaard, 2005

We report on a 25-year-old male with bipolar disorder, dysmorphic features and a deletion of the long arm of Y chromosome. A potential association between sex chromosome abnormalities and a susceptibility to major psychiatric disorders has been documented. However there have been very few reports on the coincidence of Y chromosome aberrations with bipolar disorder. Cytogenetic studies have contributed to the identification of several disease genes. Karyotyping of patients with bipolar disorder in order to identify candidate regions for linkage studies has been recommended.

Keywords: bipolar disorder; chromosomal abnormality; chromosome Y; deletion

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1399-5618.2005.00198.x

Affiliations: 1: Psychiatry 2: Reproduction and Andrology, University Medical School, Lublin, Poland

Publication date: 2005-06-01