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miRNA in mycosis fungoides and skin inflammation

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Abstract:

In this mini‐review, progress in our understanding of the link between miRNAs and cytokines in inflammatory skin diseases is highlighted with focus on miR‐155 in mycosis fungoides (MF). MF is the most common variant of cutaneous T‐cell lymphoma (CTCL) and is characterized by malignant T‐cell proliferation in a chronic inflammatory environment in affected skin. Recent data show that miR‐155 is expressed in situ by both malignant and non‐malignant T cells, induced via the STAT5 signal pathway and IL‐2Rbeta/gamma cytokines, and thus suggest the importance of miR‐155 in malignant proliferation, clinical diagnosis, and prognosis in CTCL.

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/apm.12186

Publication date: November 1, 2013

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