Skip to main content

In vitro synergy of oxacillin and gentamicin against coagulase‐negative staphylococci from blood cultures of neonates with late‐onset sepsis

Buy Article:

$51.00 plus tax (Refund Policy)

Abstract:

Coagulase‐negative staphylococci (CoNS) are the leading cause of late‐onset sepsis (LOS) in neonates. Increasing resistance of CoNS to beta‐lactams and aminoglycosides has led to widespread use of vancomycin, which in turn may lead to resistance to vancomycin. Thus, combination therapy of LOS has been advocated. We aimed to determine the interaction of oxacillin and gentamicin against CoNS. In 2005, 34 isolates of oxacillin‐ and gentamicin‐resistant CoNS were obtained from blood samples of neonates with LOS. Combination effect was tested using the checkerboard method, E‐test with the other antibiotic incorporated in the medium (E‐test‐1) and two E‐test strips placed in a cross‐formation (E‐test‐2). Of 34 isolates 61.8%, 53% and 73.5% revealed synergy or an additive effect when tested by the checkerboard method, E‐test‐1 and E‐test‐2, respectively. Results of all three tests were concordant for six (17.6%) isolates, four showing synergy, and two indifference. Our in vitro results support that combination therapy with penicillinase‐resistant penicillin and aminoglycoside can be an alternative to vancomycin.

Document Type: Research Article

DOI: https://doi.org/10.1111/apm.12048

Publication date: 2013-09-01

  • Access Key
  • Free ContentFree content
  • Partial Free ContentPartial Free content
  • New ContentNew content
  • Open Access ContentOpen access content
  • Partial Open Access ContentPartial Open access content
  • Subscribed ContentSubscribed content
  • Partial Subscribed ContentPartial Subscribed content
  • Free Trial ContentFree trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more