Skip to main content

EBV+ cutaneous B‐cell lymphoproliferation of the leg in an elderly patient with mycosis fungoides and methotrexate treatment

Buy Article:

$43.00 plus tax (Refund Policy)

A 77‐year‐old man with a 5‐year history of mycosis fungoides (MF) who had received several lines of therapy, including intravenous courses of Methotrexate (MTX) for the past 2 years, went on to develop several ulcerated cutaneous nodules on the left leg. Biopsy revealed diffuse sheets of EBV‐positive large B cells (CD20+ CD30 ± IgM Lambda), with an angiocentric distribution and a monoclonal IGH gene rearrangement. Although the pathological features were diagnostic for an EBV‐positive diffuse large B‐cell lymphoma (DLBCL), several possibilities could be considered for assignment to a specific entity: EBV‐positive DLBCL of the elderly, methotrexate‐induced lymphoproliferative disorder (LPD), lymphomatoid granulomatosis, or the more recently described EBV‐positive mucocutaneous ulcer. The development of EBV+ lymphoproliferations has been reported in two other patients with MF under MTX, and occurred as skin lesions of the leg in one of these and in the current case, which may question the relatedness to primary cutaneous DLCBL, leg‐type.
No References
No Citations
No Supplementary Data
No Data/Media
No Metrics

Document Type: Research Article

Publication date: 2013-01-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more