Function of adrenomedullin in inflammatory response of liver against LPS‐induced endotoxemia

$48.00 plus tax (Refund Policy)

Download / Buy Article:

Abstract:

Adrenomedullin (AM) is a hypotension‐causing peptide that was originally isolated from human pheochromocytoma cells, and it has been found to be expressed in various organs, including the liver. As the individual physiological and pathophysiological properties of AM peptide in the liver during endotoxemia in vivo has not yet been examined, we investigated this in experimental endotoxemia using heterozygote AM‐deficient (AM+/−) mice. The AM concentration of AM+/− mice was significantly lesser than that of wild‐type (WT) mice in lipopolysaccharide (LPS)‐induced endotoxemia. After administering LPS, the survival rate for AM+/− mice was significantly lower than that for WT mice. Also, expressions of IL‐1β mRNA, and TNF‐α mRNA, and NF‐κB p65 in the liver were markedly increased and serum ALT greatly elevated in comparison with WT mice. However, supplementation of exogenous AM reversed the deteriorations in mortality and inflammatory responses. Therefore, we conclude that AM plays an important role in regulating systemic inflammation and may be an important intrinsic factor for protecting against liver damage in LPS‐induced endotoxemia.

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0463.2012.02892.x

Publication date: September 1, 2012

Related content

Tools

Favourites

Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more