Skip to main content

The role of CK7, Ki‐67, CD34 and vimentin in the differentiation between biliary atresia and idiopathic neonatal hepatitis in Egyptian cholestatic neonates

Buy Article:

$51.00 plus tax (Refund Policy)

Abstract:

Aiad HAS, Kandil MAH, Samaka RM, Sultan MM, Badr MT, Nada GEM. The role of ck7, ki‐67, cd34 and vimentin in the differentiation between biliary atresia and idiopathic neonatal hepatitis in egyptian cholestatic neonates. APMIS 2012; 120: 529–38.

The differentiation between biliary atresia (BA) and idiopathic neonatal hepatitis (INH) is challenging with many histological overlaps especially in the first weeks of life. This study aimed to investigate the role of immunohistochemical staining of CK7, Ki67, CD34, and vimentin in addition to other clinicopathological features in the differentiation between BA and INH. Cases included 30 infants with BA and 30 infants with INH. The diagnosis was based on clinical, laboratory, and liver biopsy examination. Female gender and elevated serum gamma glutamyle transferase were in favor of BA. Portal tract changes, such as bile ductular proliferation documented by CK7, Ki67 immunostaining and angiogenesis documented by CD34 immunostaining, favored the diagnosis of BA. Copper associated protein was positive in 70% of BA cases, but not detected in INH cases. Parenchymatous changes, such as giant cell transformation and positive iron deposition and Kupffer cell proliferation documented by vimentin immunostaining, favored the diagnosis of INH.CK7, Ki67, CD34, and vimentin are helpful adjuvant immunostaining in the differentiation between BA and INH.

Document Type: Research Article

DOI: https://doi.org/10.1111/j.1600-0463.2011.02859.x

Affiliations: 1: Department of Pathology, Faculty of Medicine, Menoufiya University, Menoufiya, Egypt 2: Department of Pathology, National Liver Institute, Menoufiya University, Menoufiya, Egypt 3: Department of Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt

Publication date: 2012-07-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more