Skip to main content

Benign apocrine papillary lesions of the breast lacking or virtually lacking myoepithelial cells—potential pitfalls in diagnosing malignancy

Buy Article:

$51.00 plus tax (Refund Policy)

Abstract:

Cserni G. Benign apocrine papillary lesions of the breast lacking or virtually lacking myoepithelial cells – potential pitfalls in diagnosing malignancy. APMIS 2012; 120: 249–52.

Two cases of apocrine papillary lesions are presented, in which myoepithelial cells were not visualized on hematoxylin and eosin‐stained slides. A complex sclerosing papillary lesion did not exhibit myoepithelial cells on p63 and CD10 immunostaining, although a thin rim of myoepithelial cell cytoplasm was revealed by smooth muscle actin, calponin, and S100 immunostains. In the other lesion, without sclerosis, myoepithelium was not detected in the central papillary cores or at the periphery of the cystic wall on hematoxylin and eosin‐stained sections or with any of the myoepithelial markers tested, although two small wall areas did display the presence of myoepithelium. These two cases strengthen the view that the lack of myoepithelium alone in apocrine lesions cannot be equated with malignancy. As recent literature reports have demonstrated that myoepithelial cells may be missing from benign apocrine changes and proliferations of different types, a reconsideration of the diagnostic criteria of the malignancy of such lesions appears essential.

Document Type: Research Article

DOI: https://doi.org/10.1111/j.1600-0463.2011.02840.x

Affiliations: Bács-Kiskun County Teaching Hospital, Kecskemét, Hungary; and University of Szeged, Faculty of Medicine, Department of Pathology, Szeged, Hungary

Publication date: 2012-03-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more