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The presence of Epstein–Barr virus (EBV) in diffuse large B-cell lymphomas (DLBCLs) in Turkey: special emphasis on ‘EBV-positive DLBCL of the elderly’

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Abstract:

Uner A, Akyurek N, Saglam A, Abdullazade S, Uzum N, Onder S, Barista I, Benekli M. The presence of Epstein–Barr virus (EBV) in diffuse large B-cell lymphomas (DLBCLs) in Turkey: special emphasis on ‘EBV-positive DLBCL of the elderly’. APMIS 2011; 119: 309–16.

Accumulated evidence has shown the importance of Epstein–Barr virus in the pathogenesis of various lymphomas. This study aimed to determine the prevalence of Epstein–Barr virus expression and its effect on survival amongst diffuse large B-cell lymphoma (DLBCL) cases from two large tertiary care centres in Turkey with a particular interest in identifying cases of ‘Epstein–Barr virus-positive DLBCL of the elderly’. Diffuse large B-cell lymphoma cases diagnosed between 1999 and 2009 were retrieved and 340 cases were used to construct tissue microarrays. The presence of Epstein–Barr virus small ribonucleic acids was examined by in situ hybridization using Epstein-Barr virus (EBV)-encoded small RNA (EBER) oligonucleotides. A total of 18 cases (5.3%) showed Epstein–Barr virus expression. Twelve cases were classified as Epstein–Barr virus-positive DLBCL of the elderly. Epstein–Barr virus-positive DLBCL cases showed a significantly inferior overall survival as compared with Epstein–Barr virus-negative cases (p < 0.001). In our study group Epstein–Barr virus expression is not prevalent in DLBCLs. Epstein–Barr virus-positive DLBCL of the elderly is also rare in the Turkish population. The presence of Epstein–Barr virus, however, is associated with poor prognosis.

Keywords: Diffuse; Epstein–Barr virus; elderly; large B-cell; lymphoma

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0463.2011.02736.x

Affiliations: 1: Department of Pathology, Medical Faculty, Hacettepe University, Ankara 2: Department of Pathology, Medical Faculty, Gazi University, Ankara 3: Hacettepe University, Oncology Institute, Ankara 4: Section of Medical Oncology, Medical Faculty, Hacettepe University, Ankara 5: Section of Medical Oncology, Medical Faculty, Gazi University, Ankara, Turkey

Publication date: April 1, 2011

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