Variable beta‐glucans production by different states of
Abstract:Bellanger A‐P, Millon L, Rognon B, Roussel S, Botterel F, Bretagne S, Reboux G. Variable beta‐glucans production by different states of Eurotium amstelodami explains differences in inflammatory responses in airway cells. APMIS 2011.
Eurotium amstelodami, a mold frequently identified in housing and farm air samples, is a suspected cause of respiratory diseases such as allergic alveolitis, atopic asthma, and organic dust toxic syndrome. This fungus is present in the air in three different states (ascospores, conidia, and hyphae). The aim of this study was to test in vitro the differential inflammatory response of airway cells exposed to 1,3 betaglucanase‐treated protein extract (BGPE), from E. amstelodami ascospores, conidia, and hyphae. Confluent cells from the A549 cell line were inoculated with calibrated BGPE issued from the three fungal forms. The levels of eight cytokines and chemokines involved in inflammatory responses were measured after 8 h of exposure. Beta‐
Document Type: Research Article
Publication date: September 1, 2011