If you are experiencing problems downloading PDF or HTML fulltext, our helpdesk recommend clearing your browser cache and trying again. If you need help in clearing your cache, please click here . Still need help? Email help@ingentaconnect.com

Differential patterns of spinal cord pathology induced by MP4, MOG peptide 35–55, and PLP peptide 178–191 in C57BL/6 mice

$48.00 plus tax (Refund Policy)

Download / Buy Article:

Abstract:

Kuerten S, Gruppe TL, Laurentius L-M, Kirch C, Tary-Lehmann M, Lehmann PV, Addicks K. Differential patterns of spinal cord pathology induced by MP4, MOG peptide 35–55 and PLP peptide 178–191 in C57BL/6 mice. APMIS 2011; 119: 336–46.

In this study we demonstrate that experimental autoimmune encephalomyelitis (EAE) induced by the MBP–PLP fusion protein MP4, MOG peptide 35–55, or PLP peptide 178–191 in C57BL/6 mice, respectively, displays distinct features of CNS pathology. Major differences between the three models resided in (i) the region-/tract-specificity and disseminated nature of spinal cord degeneration, (ii) the extent and kinetics of demyelination, and (iii) the involvement of motoneurons in the disease. In contrast, axonal damage was present in all models and to a similar extent, proposing this feature as a possible morphological correlate for the comparable chronic clinical course of the disease induced by the three antigens. The data suggest that the antigen targeted in autoimmune encephalomyelitis is crucial to the induction of differential histopathological disease manifestations. The use of MP4-, MOG:35–55-, and PLP:178–191-induced EAE on the C57BL/6 background can be a valuable tool when it comes to reproducing and studying the structural–morphological diversity of multiple sclerosis.

Keywords: Axonopathy; C57BL/6; CNS; EAE; MS; demyelination

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0463.2011.02744.x

Affiliations: 1: Department of Anatomy I, University of Cologne, Cologne, Germany 2: Department of Pathology, Case Western Reserve University, Cleveland, OH, USA

Publication date: June 1, 2011

Tools

Favourites

Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more