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Expression of midkine and endoglin in breast carcinomas with different immunohistochemical profiles

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Li LQ, Huang HL, Ping JL, Xu W, Li J, Dai LC. Expression of midkine and endoglin in breast carcinomas with different immunohistochemical profiles, APMIS 2010; 119: 103–110.

The aim of this study was to investigate the midkine and endoglin expression in breast carcinomas with five different immunohistochemical profiles and their relevance to histopathologic and clinicopathologic features. We analyzed 161 archival tissues immunohistologically. The level of midkine expression in breast cancer significantly correlated with lymph node metastasis (p = 0.001) and TNM staging (p = 0.003). High microvessel density (MVD) was associated with higher midkine reactivity group (p = 0.036). Although the basal-like subtype had higher midkine expression level and MVD, no significant difference with the other breast cancer subtypes was found. In conclusion, midkine was a promising target for tumor prognosis in clinical diagnosis and treatment. This study found no significant differences in tumor angiogenesis in different molecular subtypes of breast cancer.

Keywords: Basal-like subtype; breast carcinoma; endoglin; immunohistochemistry; midkine

Document Type: Research Article


Affiliations: 1: Huzhou Key Laboratory of Molecular Medicine 2: Department of Pathology, Affiliated Central Hospital of Huzhou Teachers College, Huzhou, Zhejiang, China

Publication date: February 1, 2011

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