Skip to main content

Expression of ezrin, Bcl-2, and Ki-67 in chondrosarcomas

Buy Article:

$51.00 plus tax (Refund Policy)

Abstract:

Söderström M, Palokangas T, Vahlberg T, Böhling T, Aro H, Carpen O. Expression of ezrin, Bcl-2, and Ki-67 in chondrosarcomas. APMIS 2010; 118: 769–76.

The aim of the present study was to investigate whether the expression of ezrin, a membrane-cytoskeleton linker and regulator of cellular signaling, is associated with clinical features of chondrosarcoma. For this purpose, we studied the expression of ezrin in 54 chondrosarcomas by immunohistochemistry and correlated the expression with other tumor characteristics, markers of proliferation, apoptosis and with clinical parameters. The intensity of ezrin staining increased with the histologic grade, and a significant positive association existed between the tumor grade and ezrin expression (p=0.0475). In addition, there was a positive correlation between the expression of ezrin and Bcl-2, an anti-apoptotic protein (r = 0.83, p < 0.0001), as well as between ezrin expression and increased proliferation as measured by Ki-67 index (r = 0.70, p < 0.0001). The positive correlation of ezrin expression with Bcl-2 and Ki-67 as well as with tumor grade suggests that an aggressive behavior of chondrosarcoma may be related to activation of ezrin and that ezrin inhibitors could provide a much needed adjuvant therapy in chondrosarcomas. In conclusion, our results indicate that high ezrin expression correlates with aggressive features of chondrosarcomas. Further analyses on the pathways downstream of ezrin are warranted.

Keywords: Bcl-2; Chondrosarcoma; Ki-67; ezrin

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0463.2010.02656.x

Affiliations: 1: Department of Pathology, University of Turku and Turku University Hospital, Turku 2: Department of Biostatistics, University of Turku, Turku 3: Department of Pathology, HUSLAB, Helsinki University Central Hospital and University of Helsinki, Helsinki 4: Department of Surgery, Turku University Central Hospital, Turku, Finland

Publication date: October 1, 2010

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more