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Outbreak of CTX-M-15-producing Klebsiella pneumoniae of sequence type 199 in a Latvian teaching hospital

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Abstract:

Dumpis U, Iversen A, Balode A, Saule M, Miklaševičs E, Giske CG. Outbreak of CTX-M-15-producing Klebsiella pneumoniae of sequence type 199 in a Latvian teaching hospital. APMIS 2010; 118: 713–6.

Previous studies on the epidemiology of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae in Latvia are lacking. ESBL-producing Klebsiella pneumoniae (n = 32) were subjected to pulsed-field gel electrophoresis (PFGE) and selected isolates to multi-locus sequence typing (MLST). Species identification and susceptibility testing were performed using VITEK2, and sequencing of blaCTX-M was performed in selected isolates. PFGE revealed one major clone (n = 23), with most of the isolates derived from the ICU. The clone harboured blaCTX-M-15, was sequence type 199 and comprised two ertapenem non-susceptible isolates. This is the first report of an ESBL outbreak in Latvia, and calls for increased epidemiological typing of ESBL-producing Enterobacteriaceae, as well as improved infection control routines.

Keywords: CTX-M; ESBL; MLST; ST; clonal complex

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0463.2010.02640.x

Affiliations: Clinical Microbiology, MTC – Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

Publication date: September 1, 2010

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