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The association of genomic variation of Epstein–Barr virus BamHI F fragment with the proliferation of nasopharyngeal carcinoma

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Abstract:

Liu Q, Han A, You S, Yang Q, Liang Y, Dong Y. The association of genomic variation of Epstein–Barr virus BamHI F fragment with the proliferation of nasopharyngeal carcinoma. APMIS 2010; 118: 657–64.

To investigate the f variant of Epstein–Barr virus (EBV) in nasopharyngeal carcinogenesis, we detected the f variant in primary nasopharyngeal carcinoma (NPC), metastatic carcinoma of the lymph node (LN), and chronic inflammation of the nasopharynx from the Guangdong region. Meanwhile, we analyzed the relationship between the f variant of EBV and LMP1, Fascin, pStat3, p53, Bcl-2, and Ki-67 expression in NPC. The results showed that the f variant of EBV was found in 11 cases of primary NPCs with LN metastasis, 12 LN metastases, and 18 primary NPCs without LN metastasis. However, only one demonstrated the F/f variant in 50 cases of chronic inflammation of the nasopharynx. The expression rate of LMP1, Fascin, pStat3, p53, Bcl-2, and Ki-67 in NPC with the f or F/f variant was higher than that with the F prototype. Furthermore, there was a significantly positive correlation between the f variant of EBV and Ki-67 expression (p < 0.05). Our study suggests that the f variant of EBV may be closely related to nasopharyngeal carcinogenesis.

Keywords: Epstein–Barr virus; Nasopharyngeal carcinoma; genomic variation; proliferation

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0463.2010.02642.x

Affiliations: 1: Department of Pathology, The First Affiliated Hospital and Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 2: Department of Pathology, Central People’s Hospital of Huizhou City, Huizhou, China

Publication date: September 1, 2010

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