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Emergence of fluoroquinolone-resistant clonal group A: clonal analysis of Norwegian and Russian E. coli isolates

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Abstract:

Strand L, Jenkins A, Grude N, Allum A-G, Mykland H-C, Nowrouzian FL, Kristiansen B-E. Emergence of fluoroquinolone-resistant clonal group A: clonal analysis of Norwegian and Russian E. coli isolates. APMIS 2010; 118: 571–77.

We describe a study of urinary tract and intestinal isolates of Escherichia coli from Norway and Russia using automated ribotyping, single nucleotide polymorphism analysis for clonal group A (CgA) supplemented with phylogrouping, virulence gene profiling and resistance profiling. CgA comprised 19% of the Norwegian UTI isolates from 2001. Two highly multiresistant fluoroquinolone-resistant CgA isolates were found. Ribotypes clustered into four major and six minor groups (ribogroups). Fluoroquinolone-resistant isolates and phylogroups A and B1 were associated with ribogroup RA. Ribogroup RB predominated among Russian UTI isolates and was predominantly phylogroup A and depleted in P-fimbriae. Ribogroup RC predominated among Norwegian UTI isolates and was rich in virulence factors (S-fimbriae, haemagglutinin and haemolysin) and predominantly phylogroup B2 and D. Ribogroup RG was associated with CgA and predominantly phylogroup D. Ribogroups RD, RE and RF had too few members for statistical analysis. The correlation between ribotype and phylogenetic group was not as strong as reported in other studies.

Keywords: CgA; E.coli; clonality; fluoroquinolone resistance; phylogenetic group; ribotyping

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0463.2010.02623.x

Affiliations: 1: Unilabs Telelab, Skien 2: Telemark University College, Bø, Norway 3: Department of Microbiology, University of Gothenburg, Gothenburg, Sweden

Publication date: August 1, 2010

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