Apoptosis of Hodgkin–Reed–Sternberg cells in classical Hodgkin lymphoma revisited

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Benharroch D, Einav I, Feldman A, Levy A, Ariad S, Gopas J. Apoptosis of Hodgkin–Reed–Sternberg cells in classical Hodgkin lymphoma revisited. APMIS 2010; 118: 339–45.

We scrutinized the role of apoptosis of the Hodgkin–Reed–Sternberg (HRS) cells in classical Hodgkin lymphoma (cHL) and critically reviewed its features in the light of conflicting evidence. In this study, we found that tumor cells in this neoplasm showed inhibition of apoptosis in 55% of the 217 cHL cases only. It is also suggested that the two factors considered responsible for apoptosis inhibition in HRS cells, nuclear factor-κB and the latent membrane protein-1 of the Epstein–Barr virus, do not correlate with apoptosis inhibition, in contrast with the findings in the consensual pathogenetic scheme. The most significant association of HRS cell apoptosis was with p53, the negative expression of which related with a high apoptotic index (p = 0.001). These findings support our contention that the role of apoptosis in the HRS cells of Hodgkin lymphoma has not been completely elucidated and is at variance with that in the consensus.

Keywords: Hodgkin lymphoma; NF-κB; apoptotic index; measles virus

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0463.2010.02600.x

Affiliations: 1: Department of Pathology, Soroka University Medical Center, Beer-Sheva 2: Department of Epidemiology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 3: Department of Oncology, Soroka Univ. Medical Center, Beer-Sheva 4: Department of Microbiology-Immunology, Faculty of Health Sciences, Ben Gurion University, Beer-Sheva, Israel

Publication date: May 1, 2010

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