Epitope-specific anti-neutrophil cytoplasmic antibodies: Do they matter? Can they be detected?

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Abstract:

Specks U. Epitope-specific anti-neutrophil cytoplasmic antibodies: Do they matter? Can they be detected? APMIS 2009; 177: 63–6.

Proteinase 3 (PR3)-anti-neutrophil cytoplasmic antibodies (ANCA) and myeloperoxidase (MPO)-ANCA are suggested to play a pathogenic role as they are closely related to the small-vessel vasculitis syndromes, Wegener's granulomatosis and microscopic polyangiitis. A large body of in vitro and animal experiments supports this concept. The mechanisms of action involve a direct interaction between ANCA and its antigen. The epitope specificity of ANCA may therefore influence the functional effects of ANCA and/or may reflect the mechanisms behind different disease manifestations or disease courses.

Keywords: ANCA; chimeric molecules; conformational epitopes; epitope specificity; monoclonal antibodies

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0463.2009.02503.x

Affiliations: Thoracic Disease Research Unit, Division of Pulmonary and Critical Care Medicine, Mayo Clinic and Foundation, Rochester, MN, USA

Publication date: June 1, 2009

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