Large-scale genomic instability in colon adenocarcinomas and correlation with patient outcome

$48.00 plus tax (Refund Policy)

Download / Buy Article:

Abstract:

Bondi J, Pretorius M, Bukholm I, Danielsen H. Large-scale genomic instability in colon adenocarcinomas and correlation with patient outcome. APMIS 2009; 117: 730–6.

The purpose of this study was to evaluate the association between DNA content in colon adenocarcinomas using high-resolution image cytometry and patient outcome. Tumours from 219 patients operated for colon adenocarcinoma were analysed using high-resolution image cytometry. Proteins involved in cell cycle propulsion (cyclins A, D1, D3 and E) and cell proliferation (c-Myc and non-membranous β-catenin) have previously been reported in the same cohort and were included in this study. The results were related to disease-free survival and to cancer-specific death. Patients with aneuploid tumours showed shorter relapse-free survival than patients with euploid tumours (univariate log-rank test, p = 0.004 and multivariate Cox regression model p = 0.009, HR 0.51, 95% CI 0.31–0.84). Also the risk of death from cancer was greater in patients with aneuploid tumours (log-rank test, p = 0.006 multivariate Cox regression model p = 0.014, HR 0.47, 95% CI 0.26–0.86). When analysing patients with Dukes stages A and B, nuclear expression of β-catenin was highly significantly associated with both shorter relapse-free survival (p < 0.005, HR 5.0, 95% CI 1.6–15.5) and cancer-specific death (p = 0.036, HR 6.9, 95% CI 1.1–42.1). DNA content in colon adenocarcinomas measured by image cytometry is an independent predictor of prognosis in our patients operated for colon adenocarcinoma.

Keywords: Colon cancer; image cytometry; ploidy; prognosis

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0463.2009.02527.x

Affiliations: 1: Surgical Department, Akershus University Hospital, Lorenskog 2: Institute for Medical Informatics (IMI), The Norwegian Radium Hospital, Oslo

Publication date: October 1, 2009

Related content

Tools

Favourites

Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more