Drug resistance and genotypic analysis of Mycobacterium tuberculosis strains from Thai tuberculosis patients
The aim of this study was the molecular characterization of primary drug-resistant Mycobacterium tuberculosis strains in Thailand. We examined a group of M. tuberculosis isolates from newly registered tuberculosis (TB) cases, collected at the largest university hospital, the Siriraj Hospital, in Thailand. Of 76 selected drug-resistant M. tuberculosis strains recovered from previously untreated pulmonary TB patients whose sputum samples were sent to this hospital, 29 (38%) were single-drug resistant, 26 (34%) multidrug resistant and two (2.6%) extensively drug resistant. Fifty (66%) strains belonged to Beijing genotype. The study demonstrate a severe problem of drug resistance among recently detected TB patients, and two large clusters of genetically similar strains indicated ongoing transmission of drug-resistant TB.
Document Type: Research Article
Affiliations: 1: Tuberculosis Unit, Department of Bacteriology, Swedish Institute for Infectious Disease Control, Solna, Sweden; 2: Molecular Mycology and Mycobacteriology Laboratory, Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok; and 3: Anti-Tuberculous Drug Research Laboratory, National Center for Genetic Engineering and Biotechnology, Thailand Science Park, Nonthaburi, Thailand 4: Department of Clinical Microbiology, Karolinska University Hospital and Karolinska Institute, Stockholm;
Publication date: 2009-04-01