Drug resistance and genotypic analysis of Mycobacterium tuberculosis strains from Thai tuberculosis patients

Authors: CHEUNOY, WATTANA; HAILE, MELLES1; CHAIPRASERT, ANGKANA2; PRAMMANANAN, THERDSAK3; CRISTEA-FERNSTRÖM, MARIANA4; VONDRACEK, MARTIN4; CHRYSSANTHOU, ERJA4; HOFFNER, SVEN1; PETRINI, BJÖRN4

Source: Apmis, Volume 117, Number 4, April 2009 , pp. 286-290(5)

Publisher: Wiley-Blackwell

Buy & download fulltext article:

OR

Price: $48.00 plus tax (Refund Policy)

Abstract:

Cheunoy W, Haile M, Chaiprasert A, Prammananan T, Cristea-Fernström M, Vondracek M, Chryssanthou E, Hoffner S, Petrini B. Drug resistance and genotypic analysis of Mycobacterium tuberculosis strains from Thai tuberculosis patients. APMIS 2009; 117: 286–90.

The aim of this study was the molecular characterization of primary drug-resistant Mycobacterium tuberculosis strains in Thailand. We examined a group of M. tuberculosis isolates from newly registered tuberculosis (TB) cases, collected at the largest university hospital, the Siriraj Hospital, in Thailand. Of 76 selected drug-resistant M. tuberculosis strains recovered from previously untreated pulmonary TB patients whose sputum samples were sent to this hospital, 29 (38%) were single-drug resistant, 26 (34%) multidrug resistant and two (2.6%) extensively drug resistant. Fifty (66%) strains belonged to Beijing genotype. The study demonstrate a severe problem of drug resistance among recently detected TB patients, and two large clusters of genetically similar strains indicated ongoing transmission of drug-resistant TB.

Keywords: Beijing genotype; DR-TB; MDR-TB; Tuberculosis; XDR-TB; drug resistance

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0463.2009.02438.x

Affiliations: 1: Tuberculosis Unit, Department of Bacteriology, Swedish Institute for Infectious Disease Control, Solna, Sweden; 2: Molecular Mycology and Mycobacteriology Laboratory, Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok; and 3: Anti-Tuberculous Drug Research Laboratory, National Center for Genetic Engineering and Biotechnology, Thailand Science Park, Nonthaburi, Thailand 4: Department of Clinical Microbiology, Karolinska University Hospital and Karolinska Institute, Stockholm;

Publication date: April 1, 2009

Tools

Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content

Text size:

A | A | A | A
Share this item with others: These icons link to social bookmarking sites where readers can share and discover new web pages. print icon Print this page