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Drug resistance and genotypic analysis of Mycobacterium tuberculosis strains from Thai tuberculosis patients

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Abstract:

Cheunoy W, Haile M, Chaiprasert A, Prammananan T, Cristea-Fernström M, Vondracek M, Chryssanthou E, Hoffner S, Petrini B. Drug resistance and genotypic analysis of Mycobacterium tuberculosis strains from Thai tuberculosis patients. APMIS 2009; 117: 286–90.

The aim of this study was the molecular characterization of primary drug-resistant Mycobacterium tuberculosis strains in Thailand. We examined a group of M. tuberculosis isolates from newly registered tuberculosis (TB) cases, collected at the largest university hospital, the Siriraj Hospital, in Thailand. Of 76 selected drug-resistant M. tuberculosis strains recovered from previously untreated pulmonary TB patients whose sputum samples were sent to this hospital, 29 (38%) were single-drug resistant, 26 (34%) multidrug resistant and two (2.6%) extensively drug resistant. Fifty (66%) strains belonged to Beijing genotype. The study demonstrate a severe problem of drug resistance among recently detected TB patients, and two large clusters of genetically similar strains indicated ongoing transmission of drug-resistant TB.

Keywords: Beijing genotype; DR-TB; MDR-TB; Tuberculosis; XDR-TB; drug resistance

Document Type: Research Article

DOI: https://doi.org/10.1111/j.1600-0463.2009.02438.x

Affiliations: 1: Tuberculosis Unit, Department of Bacteriology, Swedish Institute for Infectious Disease Control, Solna, Sweden; 2: Molecular Mycology and Mycobacteriology Laboratory, Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok; and 3: Anti-Tuberculous Drug Research Laboratory, National Center for Genetic Engineering and Biotechnology, Thailand Science Park, Nonthaburi, Thailand 4: Department of Clinical Microbiology, Karolinska University Hospital and Karolinska Institute, Stockholm;

Publication date: 2009-04-01

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