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Solitary fibrous tumour of the kidney with sarcomatous overgrowth

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Magro G, Emmanuele C, Lopes M, Vallone G, Greco P. Solitary fibrous tumour of the kidney with sarcomatous overgrowth. Case report and review of the literature. APMIS 2008;116:1020–5.

Solitary fibrous tumour (SFT) rarely occurs in the kidney, with only one case exhibiting malignant behaviour. We report the case of a typical SFT of the kidney with sarcomatous overgrowth in a 34-year-old woman. This malignant component, grossly apparent as a nodular area arising in the context of the main tumour mass, consisted of CD34+ mitotically active atypical plump spindle- to epithelioid-shaped cells, including pleomorphic multinucleated giant cells. A novel immunohistochemical finding was diffuse and strong S-100 protein expression by sarcomatous cells. This should be kept in mind by pathologists to avoid confusion with other S-100 protein-positive malignant neoplasms.

Keywords: S-100 protein; Solitary fibrous tumour; dedifferentiation; kidney; malignant

Document Type: Research Article


Affiliations: 1: Servizio di Anatomia Patologica, Ospedale Umberto I, Enna 2: Unità Operativa di Urologia, Azienda Ospedaliera Vittorio Emanuele, Gela, Caltanissetta, Italy 3: Dipartimento G.F. Ingrassia, Policlinico Universitario G. Rodolico, Anatomia Patologica, Università di Catania, Catania

Publication date: November 1, 2008


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