Skip to main content

Platelet deposition in rabbit common carotid arteries promoted by arterial stenosis and spasm: A quantitative and morphological study

Buy Article:

$43.00 plus tax (Refund Policy)

Jørgensen L, Straume B, Mustard JF. Platelet deposition in rabbit common carotid arteries promoted by arterial stenosis and spasm. A quantitative and morphological study. APMIS 2008;116:801–10.

Coronary arteriograhy in patients with ischemic heart disease often shows spasm of the coronary arteries. The question is whether spasm is a triggering factor for thrombosis in a stenotic artery. If so, what are the mechanisms for this? A stenosing teflon ring was applied to the right common carotid artery of anesthetized rabbits and l-nor-epinephrine was dripped over the outer surface of both carotid arteries, causing spasm. In control animals an indifferent solution did not cause spasm. Nineteen rabbits were killed 30 min or 24 h after treatment. Microscopically, arteries with stenosis and spasm contained thrombi nearby the stenosis significantly more often than arteries in control animals. In another 14 rabbits, killed at 30 min, the number of platelets on the intimal surface away from the stenosis was quantified. In arteries with both stenosis and spasm the counts were significantly greater than in arteries with no treatment. The intimal surface in stenotic and spastic arteries showed assumed imprints of eddying flow and endothelial injury downstream and upstream of the stenosis. Spastic arteries showed increased folding of the internal elastic membrane, altered endothelial cells, and adhering platelets. Spasm in a rabbit artery with a preformed stenosis facilitates thrombosis probably by creating increased flow disturbances. Spasm may induce endothelial injury, causing adherence of platelets.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Arterial spasm; arterial stenosis; disturbed arterial flow; endothelial injury; experimental arterial thrombosis

Document Type: Original Article

Affiliations: 1: Department of Community Medicine, University of Tromsø, Tromsø, Norway 2: Department of Pathology, McMaster University, Hamilton, Ontario, Canada

Publication date: 2008-09-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more