Expression of NEDD-1, a PTEN regulator, in gastric and colorectal carcinomas

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Abstract:

Kim SS, Yoo NJ, Jeong EG, Kim MS, Lee SH. Expression of NEDD-1, a PTEN regulator, in gastric and colorectal carcinomas. APMIS 2008;116:779–84.

Recent studies have disclosed that NEDD4-1 regulates PTEN activity by ubiquitination. NEDD4-1 negatively regulates PTEN in cytosol and acts as an oncogenic protein. By contrast, NEDD4-1 promotes PTEN nuclear import and acts as a tumor suppressor. Despite the importance of NEDD4-1 in PTEN regulation in cancer cells, expression of NEDD4-1 protein in cancer tissues is unknown. The aim of this study was to analyze NEDD4-1 expression in colorectal and gastric cancer tissues. We investigated NEDD4-1 protein expression in 103 colorectal and 60 gastric carcinoma tissues by immunohistochemistry using a tissue microarray approach. In the cancers, expression of NEDD4-1 was detected in 82 (80%) of the colorectal carcinomas and 45 (75%) of the gastric carcinomas in cytoplasm. By contrast, the normal mucosal cells of both stomach and colon showed no or very weak expression of NEDD4-1. There was no significant association of NEDD4-1 expression with clinicopathologic characteristics, including invasion, metastasis and stage. Our data indicate that NEDD4-1 overexpression is a feature of both colorectal and gastric carcinomas. The increased expression of NEDD4-1 in malignant gastric and colorectal cells compared to their normal epithelial cells suggests that NEDD4-1 expression may play a role in colorectal and gastric cancer development.

Keywords: NEDD4-1; colorectal carcinoma; expression; gastric carcinoma

Document Type: Original Article

DOI: http://dx.doi.org/10.1111/j.1600-0463.2008.00999.x

Affiliations: Pathology

Publication date: September 1, 2008

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