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If it's not CK5/6 positive, TTF-1 negative it's not a squamous cell carcinoma of lung

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Downey P, Cummins R, Moran M, Gulmann C. If it's not CK5/6 positive, TTF-1 negative it's not a squamous cell carcinoma of lung. APMIS 2008;116:526–9.

Novel targeted treatment of non-small cell lung cancer (NSCLC) requires accurate classification of NSCLC as squamous cell carcinoma (SCC) and adenocarcinoma (AC). This study details the CK5/6 and TTF-1 immunoprofile of surgical resections of 45 NSCLCs (24 ACs and 21 SCCs) in tissue microarrays. All SCCs were CK5/6 positive, TTF-1 negative. 20 of 24 adenocarcinomas had the reverse pattern. In conclusion, all SCCs in this study were CK5/6 positive and TTF-1 negative, and therefore tumours that do not display this phenotype are unlikely to be SCCs. CK5/6 and TTF-1 is therefore a practical panel for the distinction between pulmonary SCC from AC in routine histopathology practice.
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Keywords: CK5/6; Lung cancer; TTF-1; adenocarcinoma; squamous cell carcinoma

Document Type: Research Article

Affiliations: 1: Department of Pathology, Royal College of Surgeons in Ireland, Dublin, Ireland 2: Department of Pathology, Beaumont Hospital, Dublin

Publication date: 2008-06-01

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