Skip to main content

Evolution of human immunodeficiency virus type 1 serotypes in northern Tanzania: a retrospective study

Buy Article:

$51.00 plus tax (Refund Policy)


Nyombi BM, Nkya W, Barongo L, Bjune G, Kristiansen KI, Müller F, Holm-Hansen C. Evolution of human immunodeficiency virus type 1 serotypes in northern Tanzania: a retrospective study: APMIS 2008;116:507–14.

The HIV-1 epidemic in Tanzania is characterized by the circulation of heterogeneous virus subtypes. A retrospective study was conducted to determine the changing pattern of circulating HIV-1 subtypes in northern Tanzania. A peptide-binding enzyme immunoassay (PEIA) was employed to analyse 305 HIV-1 positive serum and plasma samples collected between 1985 and 2005. Samples were serotyped using synthetic peptides representing HIV-1 genotypes A–E derived from consensus gp120 V3 sequences. Plasma samples collected in 2005 were V3 genotyped for comparison with PEIA results. In 1985, serotypes A and D were co-circulating while serotype C was first detected in 1990. In 2001 and 2005, serotype C was the most prevalent, serotype A was stable, and serotype D was declining. PEIA is relatively rapid and simple to perform compared to molecular approaches, and is a valuable epidemiological tool in regions with limited resources. HIV-1 classification into serotypes based on antigenic V3 diversity may be a useful screening tool for the identification of HIV-1 variants with regard to diagnosis, treatment, disease progression and candidate vaccine development.

Keywords: HIV-1; HIV-1 serotypes; PEIA; Tanzania

Document Type: Research Article


Affiliations: 1: Kilimanjaro Christian Medical College, Moshi, Tanzania 2: Institute of General Practice and Community Medicine, Faculty of Medicine, University of Oslo, Oslo 3: Institute of Microbiology, Rikshospitalet, University of Oslo, Oslo

Publication date: June 1, 2008

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Partial Open Access Content
Partial Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more