Skip to main content

Acute megakaryoblastic leukemia mimicking small round cell tumor with novel t(1;5)(q21;p13)

Buy Article:

$51.00 plus tax (Refund Policy)

Bozkurt SU, Berrak SG, Tugtepe H, Canpolat C, Palanduz S, Tecimer T. Acute megakaryoblastic leukemia mimicking small round cell tumor with novel t(1;5)(q21;p13). APMIS 2008;116:163–6.

Acute megakaryoblastic leukemia is a relatively rare form of acute leukemia that has heterogeneous blast morphology and karyotypic abnormalities. An 8-month-old boy with a retroperitoneal mass was diagnosed as having acute megakaryoblastic leukemia that initially presented as small round cell tumor of childhood. Bone marrow aspiration showed syncytial groups of atypical medium sized cells with scant cytoplasm and fine nuclear chromatin. Retroperitoneal mass biopsy showed several lymph nodes with cohesive clusters of neoplastic cells that demonstrated expression of Factor VIII. Flow cytometric analysis of the second bone marrow aspiration showed CD 61 positivity. Karyotypic analysis of bone marrow cells showed a novel translocation, (1;5)(q21;p13).
No References
No Citations
No Supplementary Data
No Data/Media
No Metrics

Keywords: Acute megakaryoblastic leukemia; cytogenetics; metastatic carcinoma; small round cell tumor; t(1;5)

Document Type: Research Article

Affiliations: 1: Pediatric Hematology Oncology 2: Pediatric Surgery 3: Istanbul University, Istanbul Medical Faculty, Department of Internal Medicine, Division of Medical Genetics, Istanbul, Turkey 4: Pathology

Publication date: 2008-02-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more