Skip to main content

Prostate-specific antigen-positive extramammary Paget's disease––association with prostate cancer

Buy Article:

$51.00 plus tax (Refund Policy)

Abstract:

Hammer A, Hager H, Steiniche T. Prostate-specific antigen-positive extramammary Paget's disease – association with prostate cancer. APMIS 2008;116:81–88.

Extramammary Paget's disease (EMPD) is a rare intraepidermal adenocarcinoma that primarily affects the anogenital region. Cases of EMPD reacting with PSA (prostate-specific antigen) have previously been associated with underlying prostate cancer. However, a recent case of EMPD in our department has led us to question the value of PSA as an indicator of underlying prostate cancer. Clinical and pathological data were obtained for 16 cases of EMPD. Formalin-fixed, paraffin-embedded tissue blocks from the primary skin lesions were investigated using PSA and other immunohistochemical markers. 5 of the 16 cases of EMPD stained positive for PSA (2 women and 3 men). However, no reactivity was seen for the prostatic marker P501S. Three of the five patients had been diagnosed with internal malignant disease–two with prostate cancer, stage 1. Immunohistochemical investigations of the tumour specimens from the prostate revealed an immunoprofile which was very different from that of the primary skin lesion. In our study, no cases of EMPD with PSA positivity seem to represent an extension of an underlying prostatic adenocarcinoma. PSA positivity can be seen in cases of EMPD without associated adenocarcinoma of the prostate.

Keywords: Extramammary Paget's disease; PSA; immunohistochemistry; prostate cancer; prostate-specific antigen

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0463.2008.00816.x

Affiliations: 1: Department of Pathology, Aarhus University Hospital, Aarhus, Denmark 2: Department of Pathology, Vejle Hospital, Vejle

Publication date: January 1, 2008

mksg/apm/2008/00000116/00000001/art00012
dcterms_title,dcterms_description,pub_keyword
6
5
20
40
5

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more