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Primary hepatic clear cell myomelanocytic tumor: Case report and review of the literature

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Abstract:

Larbcharoensub N, Karnsombut P, Jatchavala J, Wasutit Y, Nitiyanant P. Primary hepatic clear cell myomelanocytic tumor. Case report and review of the literature. APMIS 2007;115:1454–9.

A case of hepatic clear cell myomelanocytic tumor in a 31-year-old woman presenting clinically with abdominal pain is reported. Histopathologic examination showed a lesion characterized by a population of large epithelioid cells with clear or eosinophilic granular cytoplasm, rich in glycogen. Immunohistochemically, the tumor cells were positive for HMB-45, Melan-A and muscle-specific actin, but negative for epithelial markers, desmin, S-100 protein, and neuroendocrine markers. Ultrastructurally, the tumor cells had abundant glycogen, well-developed rough endoplasmic reticulum, microtubules and aberrant melanosomes. Clinical and pathologic features with a brief review of the relevant literature for hepatic CCMMT as a variant of perivascular epithelioid cell tumor (PEComa) are discussed.

Keywords: Clear cell myomelanocytic tumor; PEComa; liver; perivascular epithelioid cell

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0463.2007.00733.x

Affiliations: 1: Pathology 2: Surgery, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

Publication date: December 1, 2007

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