Localized lymphoid hyperplasia of the rectum representing progressive transformation of the germinal center: A report of two cases

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Abstract:

Kojima M, Iijima M, Shimizu K, Hoshi K. Localized lymphoid hyperplasia of the rectum representing the progressive transformation of germinal center. A report of two cases. APMIS 2007;115:1432–6.

Histologically, benign lymphoid hyperplasia (BLH) of the rectum is usually characterized by large lymphoid follicles with active germinal centers, and a narrow surrounding mantle zone and marginal zone. We present two cases of BLH of the rectum demonstrating progressive transformation of the germinal center (PTGC). The patients were 50- and 71-year-old Japanese women. Colonoscopy demonstrated small sessile polyps in both cases. The resected specimen contained numerous lymphoid follicles with active germinal centers and a portion of the lymphoid follicles exhibited PTGC. The area showing PTGC contained a few large lymphoid cells resembling lymphocytic and histiocytic Reed-Sternberg cells of nodular lymphocyte-predominant Hodgkin lymphoma. These PTGC contained small- to-medium clusters of epithelioid cells in both cases. In situ hybridization studies demonstrated scattered Epstein-Barr virus (EBV)-encoded small RNA-positive medium and large lymphoid cells and crypt epithelium in both lesions. EBV may be involved in the etiology of a subset of BLH of the rectum. However, reactivity of lymphoid cells for EBV has been reported in lymphoid tissues in a high percentage of “normal” individuals. The etiology of BLH of the rectum remains unclear.

Keywords: Benign lymphoid hyperplasia; MALT lymphoma; progressive transformation of germinal center; rectum

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0463.2007.00815.x

Affiliations: Pathology and Clinical Laboratories, Gunma Cancer Center Hospital, Ohta

Publication date: December 1, 2007

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