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Endometrial stromal nodule embedded into term placenta

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Karpf EF, Poetsch B, Langner C, Nogales FF, Regauer S. Endometrial stromal nodule embedded into term placenta. Case report. APMIS 2007;115:1302–1305.

A 28-year-old patient presented with a 5 cm endometrial stromal tumor situated at the uteroplacental interface, which was diagnosed ultrasonographically at the 28th week of pregnancy. The tumor was asymptomatic and closely attached to the decidua; after a normal term delivery, it was revealed to be embedded within the placenta. Microscopically, the neoplasm had a high mitotic rate and characteristic features of endometrial stromal tumor, such as CD10, progesterone receptor positivity, and an expansile linear, non-infiltrative pushing border. There were also pregnancy-related changes such as decidualization and myxoid change. In conclusion, the lesion was considered a benign endometrial stromal nodule with an unusual morphology and increased proliferation rate due to the hormonal stimuli of pregnancy.

Keywords: Endometrial stromal tumor; endometrial stromal nodule; placenta; ultrasonographic diagnosis; pregnancy neoplasms

Document Type: Research Article


Affiliations: 1: Private Practice for Gynecology and Obstetrics, Leibnitz, Austria 2: Institute of Pathology, Medical University of Graz, Graz 3: Department of Pathology, University of Granada, Granada, Spain

Publication date: November 1, 2007


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