Mixed testicular germ cell tumor in an adult with cryptorchidism and Down's syndrome

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Abstract:

Kuroda N, Amano S, Shiotsu T, Tamura M, Hes O, Michal M, Lee GH. Mixed testicular germ cell tumor in an adult with cryptorchidism and Down's syndrome. Case report. APMIS 2007;115:1292–1295.

We here present a case of mixed testicular germ cell tumor in an adult with cryptorchidism and Down's syndrome. A 20-year-old Japanese man with a mass in the left inguinal region underwent orchidectomy as a left testicular tumor was suspected. Histology showed a mixed germ-cell tumor with embryonal carcinoma and yolk sac tumor with syncytiotrophoblastic giant cells occurring in a cryptorchid testis. Chromosomal analysis of peripheral lymphocytes disclosed a karyotype of 47,XY,+21[20]. Our case provides further evidence that these three conditions—Down's syndrome, cryptorchidism and testicular germ cell tumor—may be closely associated. To our knowledge this is the first case of mixed germ cell tumor arising in a patient with Down's syndrome and cryptorchidism.

Keywords: Down's syndrome; cryptorchidism; embryonal carcinoma; non-seminoma; yolk sac tumor

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0643.2007.00497.x

Affiliations: 1: Urology, Kochi Red Cross Hospital, Kochi, Japan 2: Department of Pathology, Charles University Hospital Plzen, Czech Republic 3: Department of Pathology, Kochi Medical School, Kochi University, Kochi, Japan

Publication date: November 1, 2007

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