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Performance of commercial latex agglutination tests for the differentiation of Candida dubliniensis and Candida albicans in routine diagnostics

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Abstract:

Chryssanthou E, Fernandez V, Petrini B. Performance of commercial latex agglutination tests for the differentiation of Candida dubliniensis and Candida albicans in routine diagnostics. APMIS 2007;115:1281–1284.

Candida dubliniensis is phenotypically similar to Candida albicans and may therefore be underdiagnosed in the clinical microbiology laboratory. The performance of Bichro-Dubli latex agglutination test for rapid species identification of C. dubliniensis was prospectively evaluated on 111 vaginal and 118 respiratory isolates. These had presumptively been identified as C. albicans/C. dubliniensis by their green colonies on CHROMagar Candida plates. Bichro-Dubli test identifed 2 (1.8%) vaginal and 6 (5.1%) respiratory isolates as C. dubliniensis. The test was also positive for 37 C. dubliniensis control strains characterised by 18S-28S DNA-sequencing. Bichro-Dubli test is thus a sensitive and accurate tool for rapid diagnostics in routine laboratories.

Keywords: Candida dubliniensis; latex agglutination; monoclonal antibodies

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0643.2007.00801.x

Affiliations: 1: The Swedish Institute for Infectious Disease Control, Stockholm, Sweden 2: Department of Clinical Microbiology, Karolinska University Laboratory, Solna

Publication date: November 1, 2007

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